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Jiu-Chiuan Chen, MD, MPH, ScD

Professor of Population & Public Health Sciences

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Phone +1 323 442 2949
Email jcchen@usc.edu
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Overview

Jiu-Chiuan (JC) Chen is a Professor of Population & Public Health Sciences and Neurology. Dr. Chen is a physician-epidemiologist with formal training in Internal Medicine, Environmental and Occupational Medicine, Epidemiologic Methods (Clinical; Occupational; Environmental), and Environmental Health Sciences. Chen brings extensive knowledge in medicine and toxicology together with sophisticated skills in quantitative methods to study environments and chronic disease epidemiology and elucidate the biological underpinnings of environmental influences on human health, in order to reduce the resulting environmental health disparities especially among the vulnerable populations.

At USC, Chen developed the AirPollBrain Network (Co-PIs: Finch & Chen), with its mission to create a research and education program in environmental neurosciences of brain health during development and aging in urban environments. To study how ambient air pollution exposures affect brain aging including Alzheimer’s disease (AD), Dr. Chen’s research team and their collaborators take the team-sciences approach that integrates state-of-the-art knowledge and tools in neurobiology of AD, population & clinical neuroimaging, mouse brain imaging, neuroinformatics and high-dimensional data analyses, brain vascular biology, inhalation exposure assessment and neurotoxicology, clinical neurology and neurosurgery, cognitive neurosciences and neuropsychology, quantitative psychology, epidemiology of AD, spatial statistics, and air pollution epidemiology.

These powerful approaches had been expanded to study how urban environmental adversities shape the neurodevelopmental and behavioral trajectories during vulnerable time periods. Chen’s team also pioneers the emerging field of environmental health disparities in AD and related dementias, investigating how environmental stressors and resilience factors interact to shape the socio-geographic disparities in dementia.

Publications

  • Neighborhood Disadvantage and Autism Spectrum Disorder in a Population With Health Insurance JAMA Psychiatry. 2024 Feb 01; 81(2):209-213. . View in PubMed
  • Comparison of PM25 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women’s Health Initiative Memory Study (WHIMS). Environ Health Perspect. 2024 Jan; 132(1):17003. . View in PubMed
  • Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype Alzheimers Dement. 2023 Dec; 19(12):5742-5754. . View in PubMed
  • Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study Environ Health Perspect. 2023 Aug; 131(8):87012. . View in PubMed
  • The relationship between optimism, MCI, and dementia among postmenopausal women Aging Ment Health. 2023 Jun; 27(6):1208-1216. . View in PubMed
  • Association between urban green space and postpartum depression, and the role of physical activity: a retrospective cohort study in Southern California Lancet Reg Health Am. 2023 May; 21:100462. . View in PubMed
  • Ambient fine particulate exposure and subcortical gray matter microarchitecture in 9- and 10-year-old children across the United States iScience. 2023 Mar 17; 26(3):106087. . View in PubMed
  • Identification of Postpartum Depression in Electronic Health Records: Validation in a Large Integrated Health Care System JMIR Med Inform. 2023 Mar 01; 11:e43005. . View in PubMed
  • Prenatal air pollution, maternal immune activation, and autism spectrum disorder Environ Int. 2023 09; 179:108148. . View in PubMed
  • Maternal exposure to aircraft emitted ultrafine particles during pregnancy and likelihood of ASD in children Environ Int. 2023 08; 178:108061. . View in PubMed
  • Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence Environ Int. 2023 07; 177:108001. . View in PubMed
  • Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018) Environ Int. 2023 07; 177:108030. . View in PubMed
  • Maternal obesity, diabetes, preeclampsia, and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring Autism. 2023 05; 27(4):916-926. . View in PubMed
  • The role of extreme heat exposure on premature rupture of membranes in Southern California: A study from a large pregnancy cohort Environ Int. 2023 03; 173:107824. . View in PubMed
  • Prenatal exposure to tailpipe and non-tailpipe tracers of particulate matter pollution and autism spectrum disorders Environ Int. 2023 01; 171:107736. . View in PubMed
  • Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models. Environ Sci Technol. 2023 01 10; 57(1):405-414. . View in PubMed
  • Modeling spatially varying compliance effects of PM25 exposure reductions on gestational diabetes mellitus in southern California: Results from electronic health record data of a large pregnancy cohort. Environ Res. 2023 08 15; 231(Pt 2):116091. . View in PubMed
  • Analysis of Heat Exposure During Pregnancy and Severe Maternal Morbidity JAMA Netw Open. 2023 09 05; 6(9):e2332780. . View in PubMed
  • Association of Antepartum and Postpartum Air Pollution Exposure With Postpartum Depression in Southern California JAMA Netw Open. 2023 10 02; 6(10):e2338315. . View in PubMed
  • Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women’s Health Initiative Environ Res. 2023 01 01; 216(Pt 3):114727. . View in PubMed
  • Associations Between Ambient Air Pollution and Cognitive Abilities from Midlife to Early Old Age: Modification by APOE Genotype J Alzheimers Dis. 2023; 93(1):193-209. . View in PubMed
  • B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women’s Health Initiative Memory Study Alzheimers Dement. 2022 Nov; 18(11):2188-2198. . View in PubMed
  • Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula Sci Total Environ. 2022 Jun 01; 823:153642. . View in PubMed
  • Rest-activity rhythms and cognitive impairment and dementia in older women: Results from the Women’s Health Initiative J Am Geriatr Soc. 2022 10; 70(10):2925-2937. . View in PubMed
  • Psychotropic medication use and Parkinson’s disease risk amongst older women Ann Clin Transl Neurol. 2022 08; 9(8):1163-1176. . View in PubMed
  • Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study PLoS Med. 2022 02; 19(2):e1003893. . View in PubMed
  • In utero exposure to near-roadway air pollution and autism spectrum disorder in children Environ Int. 2022 01; 158:106898. . View in PubMed
  • Association between blood pressure levels and cognitive impairment in older women: a prospective analysis of the Women’s Health Initiative Memory Study Lancet Healthy Longev. 2022 01; 3(1):e42-e53. . View in PubMed
  • Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences Environ Health Perspect. 2022 01; 130(1):17008. . View in PubMed
  • Exposure to air pollutant mixture and gestational diabetes mellitus in Southern California: Results from electronic health record data of a large pregnancy cohort Environ Int. 2022 01; 158:106888. . View in PubMed
  • Associations Between Changes in Loneliness and Social Connections, and Mental Health During the COVID-19 Pandemic: The Women’s Health Initiative J Gerontol A Biol Sci Med Sci. 2022 12 06; 77(Suppl 1):S31-S41. . View in PubMed
  • Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles J Gerontol A Biol Sci Med Sci. 2022 05 05; 77(5):977-985. . View in PubMed
  • Evidence of susceptibility to autism risks associated with early life ambient air pollution: A systematic review Environ Res. 2022 05 15; 208:112590. . View in PubMed
  • Association of improved air quality with lower dementia risk in older women Proc Natl Acad Sci U S A. 2022 01 11; 119(2). . View in PubMed
  • Association of sleep disturbance with Parkinson disease: evidence from the Women’s Health Initiative Menopause. 2022 01 10; 29(3):255-263. . View in PubMed
  • Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women J Gerontol A Biol Sci Med Sci. 2022 06 01; 77(6):1239-1244. . View in PubMed
  • Association of Global Cognitive Function With Psychological Distress and Adherence to Public Health Recommendations During the Coronavirus Disease 2019 Pandemic: The Women’s Health Initiative J Gerontol A Biol Sci Med Sci. 2022 12 06; 77(Suppl 1):S42-S50. . View in PubMed
  • Sleep and affective disorders in relation to Parkinson’s disease risk among older women from the Women’s Health Initiative J Affect Disord. 2022 09 01; 312:177-187. . View in PubMed
  • PM25 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women. Neurology. 2021 Feb 22; 96(8):e1190-e1201. . View in PubMed
  • Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI Environ Health Perspect. 2021 12; 129(12):127008. . View in PubMed
  • Ambient Air Pollution and Long-Term Trajectories of Episodic Memory Decline among Older Women in the WHIMS-ECHO Cohort Environ Health Perspect. 2021 09; 129(9):97009. . View in PubMed
  • Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model Environ Health Perspect. 2021 08; 129(8):87006. . View in PubMed
  • Adopting a “Compound” Exposome Approach in Environmental Aging Biomarker Research: A Call to Action for Advancing Racial Health Equity Environ Health Perspect. 2021 04; 129(4):45001. . View in PubMed
  • The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans Alzheimers Dement. 2021 02; 17(2):175-190. . View in PubMed
  • Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children JAMA Netw Open. 2021 12 01; 4(12):e2138300. . View in PubMed
  • Association of Local Variation in Neighborhood Disadvantage in Metropolitan Areas With Youth Neurocognition and Brain Structure JAMA Pediatr. 2021 08 01; 175(8):e210426. . View in PubMed
  • Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women’s Health Initiative Memory Study J Alzheimers Dis. 2021; 84(3):1267-1278. . View in PubMed
  • Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women J Alzheimers Dis. 2021; 84(4):1691-1707. . View in PubMed
  • Examining the joint effects of heatwaves, air pollution, and green space on the risk of preterm birth in California Environ Res Lett. 2020 Oct; 15(10). . View in PubMed
  • Air pollution exposure and adverse sleep health across the life course: A systematic review Environ Pollut. 2020 Jul; 262:114263. . View in PubMed
  • Fine particulate matter exposure during childhood relates to hemispheric-specific differences in brain structure Environ Int. 2020 10; 143:105933. . View in PubMed
  • J Am Geriatr Soc. 2020 09; 68(9):1970-1978. . View in PubMed
  • Associations between green space and preterm birth: Windows of susceptibility and interaction with air pollution Environ Int. 2020 09; 142:105804. . View in PubMed
  • Exposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women Environ Int. 2020 02; 135:105196. . View in PubMed
  • Associations of Hearing Loss and Menopausal Hormone Therapy With Change in Global Cognition and Incident Cognitive Impairment Among Postmenopausal Women J Gerontol A Biol Sci Med Sci. 2020 02 14; 75(3):537-544. . View in PubMed
  • Association of Visual Impairment With Risk of Incident Dementia in a Women’s Health Initiative Population JAMA Ophthalmol. 2020 06 01; 138(6):624-633. . View in PubMed
  • Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease Brain. 2020 01 01; 143(1):289-302. . View in PubMed
  • Ozone and Particulate Matter Exposure and Alzheimer’s Disease: A Review of Human and Animal Studies J Alzheimers Dis. 2020; 76(3):807-824. . View in PubMed
  • Metabolomic profiles associated with all-cause mortality in the Women’s Health Initiative Int J Epidemiol. 2020 02 01; 49(1):289-300. . View in PubMed
  • Erythrocyte omega-3 index, ambient fine particle exposure, and brain aging Neurology. 2020 08 25; 95(8):e995-e1007. . View in PubMed
  • Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort Environ Pollut. 2019 Nov; 254(Pt A):113010. . View in PubMed
  • Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder Environ Int. 2019 12; 133(Pt A):105110. . View in PubMed
  • Particulate Air Pollutants and Trajectories of Depressive Symptoms in Older Women Am J Geriatr Psychiatry. 2019 10; 27(10):1083-1096. . View in PubMed
  • Associations of gestational diabetes mellitus with residential air pollution exposure in a large Southern California pregnancy cohort Environ Int. 2019 09; 130:104933. . View in PubMed
  • Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies Front Public Health. 2019; 7:332. . View in PubMed
  • Relations of magnesium intake to cognitive impairment and dementia among participants in the Women’s Health Initiative Memory Study: a prospective cohort study BMJ Open. 2019 11 03; 9(11):e030052. . View in PubMed
  • General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women Alzheimers Dement (N Y). 2019; 5:118-128. . View in PubMed
  • Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer’s disease across imaging databases Neuroimage. 2018 12; 183:401-411. . View in PubMed
  • Trajectories of Relative Performance with 2 Measures of Global Cognitive Function J Am Geriatr Soc. 2018 08; 66(8):1575-1580. . View in PubMed
  • Longitudinal Analysis of Particulate Air Pollutants and Adolescent Delinquent Behavior in Southern California J Abnorm Child Psychol. 2018 08; 46(6):1283-1293. . View in PubMed
  • Long-Term Ambient Temperature and Externalizing Behaviors in Adolescents Am J Epidemiol. 2018 09 01; 187(9):1931-1941. . View in PubMed
  • Constrained Mixed-Effect Models with Ensemble Learning for Prediction of Nitrogen Oxides Concentrations at High Spatiotemporal Resolution Environ Sci Technol. 2017 Sep 05; 51(17):9920-9929. . View in PubMed
  • Air pollution and suicide risk: another adverse effect of air pollution? Eur J Epidemiol. 2017 11; 32(11):943-946.. View in PubMed
  • Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models Transl Psychiatry. 2017 01 31; 7(1):e1022. . View in PubMed
  • Socioeconomic disparities and sexual dimorphism in neurotoxic effects of ambient fine particles on youth IQ: A longitudinal analysis PLoS One. 2017; 12(12):e0188731. . View in PubMed
  • Ambient Air Pollution Exposures and Risk of Parkinson Disease Environ Health Perspect. 2016 Nov; 124(11):1759-1765. . View in PubMed
  • Environmental Determinants of Aggression in Adolescents: Role of Urban Neighborhood Greenspace J Am Acad Child Adolesc Psychiatry. 2016 07; 55(7):591-601. . View in PubMed
  • Sleep duration, cognitive decline, and dementia risk in older women Alzheimers Dement. 2016 Jan; 12(1):21-33. . View in PubMed
  • A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women Front Hum Neurosci. 2016; 10:495. . View in PubMed
  • Ambient air pollution and neurotoxicity on brain structure: Evidence from women’s health initiative memory study Ann Neurol. 2015 Sep; 78(3):466-76. . View in PubMed
  • The outdoor air pollution and brain health workshop Neurotoxicology. 2012 Oct; 33(5):972-84. . View in PubMed
  • The moving-window Bayesian maximum entropy framework: estimation of PM(25) yearly average concentration across the contiguous United States. J Expo Sci Environ Epidemiol. 2012 Sep; 22(5):496-501. . View in PubMed
  • Racial differences in knee osteoarthritis pain: potential contribution of occupational and household tasks J Rheumatol. 2012 Feb; 39(2):337-44. . View in PubMed
  • Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project Environ Res. 2011 Nov; 111(8):1208-14. . View in PubMed
  • Elevated serum liver enzymes and fatty liver changes associated with long driving among taxi drivers Am J Ind Med. 2011 Aug; 54(8):618-27. . View in PubMed
  • Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro Environ Health Perspect. 2011 Jul; 119(7):1003-9. . View in PubMed
  • Geographic access to health services and diagnosis with an autism spectrum disorder Ann Epidemiol. 2011 Apr; 21(4):304-10. . View in PubMed
  • Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project Arthritis Res Ther. 2011 Mar 01; 13(2):R37. . View in PubMed
  • Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women’s Health Initiative Observational Study Arthritis Care Res (Hoboken). 2011 Feb; 63(2):184-94. . View in PubMed
  • Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8 Epidemiology. 2010 Sep; 21(5):631-41. . View in PubMed
  • Geographic determinants of stroke mortality: role of ambient air pollution Stroke. 2010 May; 41(5):839-41. . View in PubMed
  • Associations of occupational tasks with knee and hip osteoarthritis: the Johnston County Osteoarthritis Project J Rheumatol. 2010 Apr; 37(4):842-50. . View in PubMed
  • Physical assault among nursing staff employed in acute care Work. 2010; 35(2):191-200. . View in PubMed
  • Limited educational attainment and radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis using data from the Johnston County (North Carolina) Osteoarthritis Project Arthritis Res Ther. 2010; 12(2):R46. . View in PubMed
  • Occupational injuries among aides and nurses in acute care Am J Ind Med. 2009 Dec; 52(12):953-64. . View in PubMed
  • Vascular function, inflammation, and variations in cardiac autonomic responses to particulate matter among welders Am J Epidemiol. 2009 Apr 01; 169(7):848-56. . View in PubMed
  • BME estimation of residential exposure to ambient PM10 and ozone at multiple time scales Environ Health Perspect. 2009 Apr; 117(4):537-44. . View in PubMed
  • Neurobehavioral effects of ambient air pollution on cognitive performance in US adults Neurotoxicology. 2009 Mar; 30(2):231-9. . View in PubMed
  • Sleep duration and risk of ischemic stroke in postmenopausal women Stroke. 2008 Dec; 39(12):3185-92. . View in PubMed
  • Prospective study of metal fume-induced responses of global gene expression profiling in whole blood Inhal Toxicol. 2008 Nov; 20(14):1233-44. . View in PubMed
  • Metabolic syndrome and inflammatory responses to long-term particulate air pollutants Environ Health Perspect. 2008 May; 116(5):612-7. . View in PubMed
  • Workplace policies and prevalence of knee osteoarthritis: the Johnston County Osteoarthritis Project Occup Environ Med. 2007 Dec; 64(12):798-805. . View in PubMed
  • Roles of safety climate and shift work on perceived injury risk: a multi-level analysis Accid Anal Prev. 2007 Nov; 39(6):1088-96. . View in PubMed
  • Obesity is a modifier of autonomic cardiac responses to fine metal particulates Environ Health Perspect. 2007 Jul; 115(7):1002-6. . View in PubMed
  • Night heart rate variability and particulate exposures among boilermaker construction workers Environ Health Perspect. 2007 Jul; 115(7):1046-51. . View in PubMed
  • Death stroked by dusty air: more mysteries to be solved Occup Environ Med. 2007 Jan; 64(1):3-4. . View in PubMed
  • Personal coronary risk profiles modify autonomic nervous system responses to air pollution J Occup Environ Med. 2006 Nov; 48(11):1133-42. . View in PubMed
  • GIS approaches for the estimation of residential-level ambient PM concentrations Environ Health Perspect. 2006 Sep; 114(9):1374-80. . View in PubMed
  • Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers Occup Environ Med. 2005 Dec; 62(12):890-4. . View in PubMed
  • Occupational factors associated with low back pain in urban taxi drivers Occup Med (Lond). 2005 Oct; 55(7):535-40. . View in PubMed
  • Seat inclination, use of lumbar support and low-back pain of taxi drivers Scand J Work Environ Health. 2005 Aug; 31(4):258-65. . View in PubMed
  • Exposure to welding fumes is associated with acute systemic inflammatory responses Occup Environ Med. 2005 Mar; 62(3):157-63. . View in PubMed
  • Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes Environ Health Perspect. 2005 Feb; 113(2):233-41. . View in PubMed
  • Occupational and personal factors associated with acquired lumbar spondylolisthesis of urban taxi drivers Occup Environ Med. 2004 Dec; 61(12):992-8. . View in PubMed
  • Using exposure prediction rules for exposure assessment: an example on whole-body vibration in taxi drivers Epidemiology. 2004 May; 15(3):293-9. . View in PubMed
  • Knee pain and driving duration: a secondary analysis of the Taxi Drivers’ Health Study Am J Public Health. 2004 Apr; 94(4):575-81. . View in PubMed
  • Predictors of whole-body vibration levels among urban taxi drivers Ergonomics. 2003 Sep 15; 46(11):1075-90. . View in PubMed
  • Source Characterization and Exposure Modeling of Gas-Phase Polycyclic Aromatic Hydrocarbon (PAH) Concentrations in Southern California Atmos Environ (1994). 2018 Mar; 177:175-186. . View in PubMed

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